The quality of pharmaceuticals has been a concern of the World Health Organization (WHO) since its inception. The setting of global standards is requested in Article 2 of the WHO Constitution, which cites as one of the Organization’s functions that it should “develop, establish and promote international standards with respect to food, biological, pharmaceutical and similar products.” Every government allocates a substantial proportion of its total health budget to medicines. This proportion tends to be greatest in developing countries, where it may exceed 40%.
Without assurance that these medicines are relevant to priority health needs and that they meet acceptable standards of quality, safety and efficacy, any health service is evidently compromised. In developing countries considerable administrative and technical effort is directed to ensuring that patients receive effective medicines of good quality. It is crucial to the objective of health for all that a reliable system of medicines control be brought within the reach of every country. The supply of essential medicines of good quality was identified as one of the prerequisites for the delivery of health care at the International Conference on Primary Health Care in Alma-Ata in 1978. Similarly, the Conference of Experts on the Rational Use of Drugs, held in Nairobi in 1985, and WHO’s Revised Drug Strategy, adopted by the World Health Assembly in May 1986, identified the effective functioning of national drug regulation and control systems as the only means to assure safety and quality of medicines. Yet the World Health Assembly continues to express great concern about the quality, safety and efficacy of medicines, particularly those products or active pharmaceutical substances imported into, or produced in, developing countries. In recent years counterfeit products have infiltrated certain markets in disquieting proportions. Since the founding of WHO, the World Health Assembly has adopted many resolutions requesting the Organization to develop international standards, recommendations and instruments to assure the quality of medicines, whether produced and traded nationally or internationally.
This international scenario enforces academia to introduce “Quality Assurance” as a specialised branch. The department inculcates the value of “Quality of Product”, process, instrument or system. Students are given knowledge about the role and importance of Quality Control (QC) and Quality Assurance (QA). The Pharmaceutical Analysis section is an indispensible part of the Quality Assurance department which includes introduction to principle, instrumentation, methods and applications of various analytical techniques including but not limited to Titrimetry, Gravimetric analysis, Spectroscopy, Chromatography, Capillary electrophoresis, Potentiometry etc. The students receive knowledge of analytical skills and hands-on training on various analytical instruments.The concept of Validation in thoroughly introduced as part of the curriculum and also as part of QA practices.The QC aspect of the department considers various quality control tests and specifications as per IP. USP, EP and BP.The department is involved in development of Analytical Techniques using UV, HPLC and HPTLC and their Validation as per ICH guidelines.The department is also involved in phytochemical screening of plant extracts in which Flash chromatography is used.
Department of Quality Assurance has been started in 2008. Department is continuously involved in different research and academic activities. Till date 82 students have completed their M. Pharm from the department. Presently 36 M. Pharm students are studying and working on different Projects like Analytical Method Development, Phytoformulation, Formulation Development, Reverse Engineering etc.
The pharmaceutics department was established in the year 1989 and the post graduate course in pharmaceutics department was started in the year 2006. The department is having intake of 24 students for M.Pharmacy. The department is continuously engaged in research and academic activities. Pharmaceutics Department is concerned with the design and development of suitable dosage form for a drug and strategies to deliver the drug to the desired site of action in the body.
Till date 106 students have completed their masters from the department and 57 M. Pharm students are studying and perusing their research activities in various fields lilke:
The department has well equipped laboratories for undergraduate and post graduate students to peruse the research work. The laboratories have equipment like single station tablet machine, 8 station rotary tablet machine, R&D tablet pan coater, centrifugation machine, Brookefield viscometer, autoclaves, hot air oven, stability Chamber etc. The department has highly experienced faculty. It has two professors, one associate professor and seven assistant professors. Department is actively involved in research activity, patents has been filed by the faculty members of the department and the research papers are published in various international and national journals. Faculty members of the department also provide consultancy to various industries.
The department of pharmacology is active since the inception of the institute and is involved in demonstrating and practicing the experiments on animals and their tissues so as to educate and train the undergraduate and postgraduate students. Later on with the stringent and vigilant move of central government on use of animals the department is abiding the rules and laws laid down from time to time about laboratory animals where the Institutional Animal Ethics Committee under the CPCSEA, New Delhi has been constituted and is in the working status.
The department has highly qualified staff and out of seven staff members two are Ph.D and are having 12-15 years of experience. Four staff members are pursuing Ph.D from Dr. Babasaheb Ambedkar Marathwada University, Aurangabad. The department has three state-of-art laboratories with an area of 80 Sq. mt. and an animal house of 100 Sq. meter. The Department provides research facility for in vivo and in vitro studies.
The department undertakes the various experiments on mice, rats, rabbits, guinea pigs and animal tissues so as to show the effects of drugs on animals and their various tissues.
The department has stopped the use of frogs and rats for the sacrifice purpose, instead of frogs and rats, the ileum tissue of hen is in current use for the invitro experiments.
The department of Pharmaceutical Chemistry is unique of its kind, not only in the region but in the Maharashtra state, being the only college having grants and equipments from all most all national funding agencies such as University grants commission, Department of Science and Technology, INSA, home University. The students and faculty of the department have been honored with various awards and prizes at national and international level. State of art laboratory with all modern equipments such as synthetic microwave, Ultrasound synthesizer with both the solid probe and probe utilized for pharmaceutics size reduction, UV, FT IR, HPLC, Rota evaporator are all the pride of the laboratory and are open for use by all the students, academicians and the researchers in the region of Marathwada.
Establishment of the department
Plants have been one of the important sources of medicines ever since the dawn of human civilization. With all advancement in the field of drug research plant source decorates prime position both in modern as well as in traditional system of medicine. Most of the Pharmaceutical industries are plant based. Among the higher plants of medicinal value, only few of them have been investigated. Even lower plants and marine plants used in this regards are negligible. Thus, the knowledge yet to be gained and its application is much more than what has been accomplished.
Now a day’s plant based pharmaceutical products, cosmetics food flavors and natural colors are of higher attraction globally. There is a definite trend to adopt plant-based products due to cumulative derogatory effects resulting from the use of antibiotics and synthetics; and except for a few cultivated crops, the availability of the plant-based materials is mainly from the natural sources like forest and wastelands. But, due to the ever increasing devastation of the forest and the concurrent indiscriminate exploitation of the crops, their availability from natural sources has declined. There is a need to introduce medicinal plant cultivation into the cropping systems of the country, which, besides meeting the demand of the industry, will also help to maintain the standards on quality, potency and chemical constituents. The folk medicines of almost all the countries of the world abound in the medicinal plants and tribal people wherever they exist, rely chiefly on herbal medicine, even today.
To Rescue Man from the Clutches of Disease is a Duty, Sacred and Obligatory, from Time Immemorial
To achieve this there are several systems of medicine practiced in the world, every system with its own basis, philosophy and therapeutics, but with one common objective that is Health for all. These systems, basically differing from each other, cannot be discounted as obsolete. They are as scientific as modern medicine if one cares to find out and work on them without prejudice.